Gigg från: Astrazeneca AB
Postdoc Fellow Understanding cellular availability and retention of PROTACs
Building design principles for extended treatment duration Astra Zeneca is a global, science-led, patient-centered biopharmaceutical company that focuses on the discovery, development and commercialization of prescription medicines for some of the world’s most serious disease. But we’re more than one of the world’s leading pharmaceutical companies. At Astra Zeneca, we 're dedicated to being a Great Place to Work where you are empowered to push the boundaries of science and fuel your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. About the Postdoc Programme Bring your expertise, apply your knowledge, follow the science and make a difference! Astra Zeneca’s Postdoc Programme is for self-motivated individuals looking to tackle exciting, high impact projects in a collaborative and innovative environment. Working with peers and professionals from a diverse set of backgrounds, together with a world class academic mentor aligned specifically to your project, you’ll be respected as a specialist, and encouraged to speak up. You’ll lead a novel and innovative research project at the interface of drug discovery and biopharmaceutical development in a multi-disciplinary scientific environment. You’ll be empowered and supported to drive the success of your project, publish papers, achieve your goals and make difference to our patients. Running alongside your research project, our postdoc training program will help you learn about drug discovery and development from industry leaders working in our innovative research laboratories and organization. About the Opportunity Together with Thomas Lundbäck, Director within the Discovery Sciences organization in Gothenburg, Sweden and Professor Pär Matsson at University of Gothenburg, we will strive to build and publish a scientific rule book for PROTACs uptake and retention by refining and applying available methodologies for cellular uptake. You will be responsible for experimental design and cell work across multiple cell model systems, methodology optimization, and quality control of results using endogenous metabolites. As a respected specialist, you’ll have the freedom and autonomy to contribute known skills, and the support to rapidly learn new approaches to follow the science, innovate and make an impact. Leveraging scientific development to springboard your career whilst making a meaningful difference to patients, science, and our business. This Postdoc position is placed within a hard-working team that generates in vitro pharmacology data for Gothenburg based drug discovery projects. As such, we offer a rewarding scientific environment in the midst of our R&D operations, with ample opportunities for in-depth findings of how we optimise compound properties towards nomination of candidate drugs. Of importance for your postdoctoral work is that you will be colocalized with and draw on the expertise of a world-leading bioanalysis team and UPLC-MS/MS equipment outputs data across multiple assays for >11,000 compounds each year. Qualification, Skills & Experience We are looking for a hands-on biologist with a background (Ph D) in cutting-edge metabolomics research and a desire to translate this knowledge to a drug discovery settling. Required: Extensive hands-on experience of cellular biology techniques applied to multiple cell lines Documented expertise in the design and execution of metabolomics studies Experienced user of UPLC-MS/MS based methods for quantifying metabolites Scientific visibility and leadership through project contributions and external publications Excellent communication skills and an ability to operate effectively in a multi-disciplinary research environment Team player, with a willingness to share and a drive to learn in everything you do Desirable: Demonstration of independent analysis and evaluation of complex data A good understanding of in vitro pharmacology Proven ability in providing technical leadership and guidance to others Excellent problem-solving skills, not limited to own area of expertise This is a 3-year programme. 2 years will be a Fixed Term Contract, with a 1-year extension which will be merit based.
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